The wastewater resistome refers to the collection of antibiotic resistance genes (ARGs) present in wastewater environments. These environments, often polluted with antibiotics and other pharmaceuticals, serve as breeding grounds for resistant bacteria. ARGs can be transferred among bacterial populations through horizontal gene transfer, exacerbating the spread of antibiotic resistance. Monitoring and mitigating the wastewater resistome is crucial to combat the global threat of antibiotic resistance, as it poses significant risks to public health by potentially reintroducing resistant bacteria into natural water systems and human communities.